Eligibility: Inclusion Criteria: 1.50-80 years old, ASA grade II-III; 2.Bilateral STN-DBS of patients with Parkinson's disease; 3.Signed informed consent. Exclusion Criteria: 1. Obstructive sleep apnea; 2. BMI \> 30kg/m2; 3. Estimated difficult airway; 4. Severe preoperative anxiety; 5. Se…

Eligibility: Parkinson's disease group Inclusion Criteria: * Have been diagnosed with Parkinsons Disease by a healthcare professional * Are at least 40 years old Exclusion Criteria: * Possess a diagnosis of autism or any other developmental disability (e.g., Down syndrome) Neurotypical g…

Eligibility: Inclusion Criteria: * Clinical diagnosis of Parkinson's disease as per a neurologist, a severity of 2-4 on the Hoehn and Yahr (H-Y) Scale * Able to receive OMM * Able to be in a supine and prone position for MyotonPRO measurements * Able to ambulate for gait measurements * Have…

Eligibility: Inclusion Criteria: * Having regular neurology follow-up and using medicine; * Hoehn and Yahr Scale Stage between 1-3 points; * Mini-Mental State Assessment Score \>24 points; Exclusion Criteria: * Having a secondary neurological disease; * Any surgery and/or trauma affecti…

Eligibility: Inclusion Criteria: * Parkinson's disease with bilateral STN DBS * Availability of pre-operative MR images (with a T1-weighted, gradient-echo sequence) and ability to get post-operative MRI or CT scans * Hoehn and Yahr stage 2-4 when off medication, and a stable antiparkinsonian…

Eligibility: Inclusion Criteria: * Patient referred for a scan or PET scan * Patient with a score \> 11 on the STAI-6 scale. * Person, speaking and understanding French * Having received complete information on the organization of the research and having signed the informed consent * Age ≥ 1…

Eligibility: Inclusion Criteria: 1. Diagnosis of Parkinson's disease 2. Hoehn and Yahr stages II-III, 3. 45-75 years old 4. able to ride a stationary upright bicycle 5. able to sign informed consent. Exclusion Criteria: 1. Have a recent history of severe heart disease, severe lung disease,…

Eligibility: Inclusion Criteria: 1. Males and females between the ages 40 - 85 with a diagnosis of idiopathic Parkinson's Disease (PD) consistent with the United Kingdom PD society brain bank criteria, 2. in Hoehn and Yahr stage 2-4, 3. a score of ≥23 on the mini-Mental Scale Examination. E…

Eligibility: Inclusion Criteria: * All included patients should fulfill the U.K Parkinson's Disease Brain Bank Criteria for idiopathic PD. * Patients with mild to moderate disease severity according to UPRS and Modified Hoehn and Yahr staging * Duration of illness from two to five years were…

Eligibility: Inclusion Criteria: * Diagnosis of Parkinsons disease * Stable dopaminergic medication (stable dose for at least 1 month) Exclusion Criteria: * Other neurological disorders * Difficulty complying due to neuropsychological dysfunction (dementia with a score of less - - than 19…

Eligibility: INCLUSION CRITERIA: Healthy Young and Old Subjects: * 20-50 or 60-90 years old * Cognitively healthy (Mini-Mental State examination ≥ 26) * Absence of significant neurological disorders Patients with prodromal Alzheimer's Disease: * Subjective cognitive complaint (corroborate…

Eligibility: Part 1 Additional Inclusion Criteria for PD: 1. diagnosis of idiopathic PD by neurologist with Hoehn and Yahr stage \< 4; 2. stable medical condition; 3. capability of walking independently without walking devices. Exclusion Criteria: 1. cognitive impairment indicated by MMSE…

Eligibility: Inclusion Criteria: * PD diagnosis according to MDS-PD criteria and for GBA-PD group, presence of heterozygous GBA mutations; * disease duration 3-7years. Exclusion Criteria: * other neurological or systemic diseases; * presence of mutations in another PD gene; * impossibility…

Eligibility: Inclusion criteria: 1. Males and females of diverse racial and ethnic backgrounds, with age across the lifespan; 2. Patients will have at least one of the forms of dystonia, including focal dystonia (e.g., laryngeal, cervical, oromandibular, blepharospasm, focal hand, musicians)…

Eligibility: Group 1: People newly referred with possible Parkinson's disease Inclusion Criteria 1\. Newly referred to UIHC Movement Disorders Clinic Exclusion Criteria 1. Prior diagnosis of Parkinson's disease 2. Confined to wheelchair or bed 3. Non-English speaking 4. Prisoner status 5.…

Eligibility: Inclusion Criteria: 1. Diagnosis of idiopathic Parkinson's disease (PD) made by a neurologist according to the Movement Disorders Society guidelines; 2. Able to walk independently for a distance of 10 meters, without walking aid; 3. Absence of a Deep Brain Stimulator; 4. Stable…

Eligibility: * INCLUSION CRITERIA: 1. Participants must be age 4 and older. 2. Participants must seek care from, or be referred to the Surgical Neurology Branch for evaluation and management of neurosurgical conditions (such as central nervous system tumors, peripheral nerve tumors, epil…

Eligibility: Inclusion Criteria: For the patient: * Patient with a diagnosis of idiopathic Parkinson's disease * Patient over 18 years ; * Patient with a Hoehn and Yahr Stage greater than or equal to 3; * Patient without major cognitive impairment defined by a MOCA score ≥21 * Patient livin…

Eligibility: * INCLUSION CRITERIA: To be eligible for entry into the study, candidates must meet all the following criteria: Be 18 years of age or older. Able to provide informed consent. Have a clinical diagnosis of one of the following as confirmed by the NIH movement disorders clinic t…

Eligibility: Inclusion Criteria: * According to the criteria of PD diagnosis of the MDS, PD patients were selected as the research object. The clinical symptoms of PD patients were consistent with Hoehn and Yahr stages 2-3. * All PD patients have maintained stable drug treatment for at least…