What's being tested:
DEVICE: Active tDCS
DEVICE: Sham tDCS
Eligibility: Inclusion Criteria: * Age: 18-65 years (inclusive) * Diagnosis: Confirmed diagnosis of multiple sclerosis (MS), including relapsing-remitting or secondary progressive subtypes * Stable Medications: Stable use of antidepressant and disease-modifying therapies (DMTs) for at least…
What's being tested:
BIOLOGICAL: rapcabtagene autoleucel (YTB323)
Eligibility: Inclusion Criteria: * Signed informed consent, and able to communicate well with the investigator and comply with the requirements of the study * Adequate renal, hepatic, cardiac, hematological, and pulmonary function * Male or female participants, ≥18 years to ≤60 years at scre…
Eligibility: Inclusion Criteria: * Patients aged 18 years or older diagnosed with MS or CIS according to the 2017 McDonald criteria. * No diagnosis of any autoimmune disease or malignancy. * No new diagnosis of autoimmune disease or malignancy during the 1-year follow-up period. * No use of…
What's being tested:
DEVICE: Indego Nomad® Powered Knee-Ankle-Foot Orthosis (P-KAFO) (Parker Hannifin Corp., Cleveland, OH)
Eligibility: Inclusion Criteria: * Regular and compliant use of a unilateral or bilateral KAFO or SCO or other passive KAFOs for impairment due to neurological or neuromuscular disease, orthopedic disease, or trauma * Cognitive ability to understand and follow the study protocol; willingness…
What's being tested:
OTHER: Flavonoid-enriched Mediterranean Diet
Eligibility: Inclusion Criteria: * Expanded Disability Status Scale (EDSS): 0-6 Exclusion Criteria: * Diagnosed digestive pathology
What's being tested:
BEHAVIORAL: Home Based Self- management and Cognitive Training Changes lives in Multiple Sclerosis (HOBSCOTCH-MS)
Eligibility: Inclusion Criteria: * Inclusion Criteria - MS Participant * Age 20 - 75 years * Diagnosis of relapsing or progressive MS * Education of at least Grade 12 or GED * Fluent in English * Subjective cognitive and memory challenges * Internet access * Telephone access…
What's being tested:
DIAGNOSTIC_TEST: Magnetic Resonance Imaging
BEHAVIORAL: Neuropsychological protocol
BEHAVIORAL: Eating habits
Eligibility: INCLUSION CRITERIA: Healthy Young and Old Subjects: * 20-50 or 60-90 years old * Cognitively healthy (Mini-Mental State examination ≥ 26) * Absence of significant neurological disorders Patients with prodromal Alzheimer's Disease: * Subjective cognitive complaint (corroborate…
What's being tested:
BEHAVIORAL: High Intensity Task Oriented Circuit Training + Telerehabilitation
Eligibility: Inclusion Criteria: * Diagnosis of primary or secondary progressive multiple sclerosis according to the McDonald criteria. * Mini-Mental State Examination (MMSE) score \> 24. * Expanded Disability Status Scale (EDSS) score ≤ 6. Exclusion Criteria: * Presence of other psychiatr…
What's being tested:
DRUG: metformin
DRUG: Placebo
Eligibility: Inclusion Criteria: 1. age between 55 and 75 years old 2. having a diagnosis of MS based on the latest McDonald criteria 3. non-active disease course (no relapses and no MRI activity) in the last 2 years as determined by the MS provider and based on the 2020 revised clinical cou…
What's being tested:
BEHAVIORAL: Action Observation + Motor Imagery
BEHAVIORAL: Nature Video
Eligibility: Inclusion Criteria: * A confirmed diagnosis of multiple sclerosis (MS) by a neurologist * No history of relapse within the past 3 months and not currently experiencing a relapse * A score of 24 or higher on the standardized Mini Mental State Examination Exclusion Criteria: * P…
Eligibility: Inclusion Criteria: * Age older than 18 years; * Diagnosis of relapsing-remitting multiple sclerosis according to McDonald criteria (2017 revisions) made between 2014 and 2024. * Signature of informed consent Exclusion Criteria: * Presence of language barrier * Presence of con…
Eligibility: Inclusion Criteria: * Patients with RRMS onset after age 50 * Patients who started their first disease-modifying therapy within 2 years of the first symptoms * Patients Treated with moderately effective disease-modifying antirheumatic drugs (DMARDs) (teriflunomide, dimethyl fuma…
What's being tested:
OTHER: Clinical Assessments
Eligibility: Inclusion Criteria: * Being 18 years of age or older, * Having been diagnosed with Multiple Sclerosis (confirmed by a neurologist), * Being in a stable phase of the disease (having not had an attack in the last 3 months), * Having preserved walking ability (EDSS score ≤6.5), * B…
What's being tested:
DRUG: Clemastine Fumarate
DRUG: Placebo
Eligibility: Inclusion Criteria: * Written informed consent must be obtained prior to any assessment being performed. * Patients diagnosed with relapsing remitting multiple sclerosis and a disease duration of \< 15 years * Male or female patients aged 18-55 years (inclusive) * Use of appropr…
What's being tested:
GENETIC: Biobanking with genetic analysis
OTHER: SF-12 questionnaire
Eligibility: Inclusion Criteria: * Patient followed for their IMID in one of the departments of the Lille University Hospital participating in the study (dermatology, internal medicine, neurology, pneumology and rheumatology) * Social insured * Have the capacity to understand the study requi…
What's being tested:
PROCEDURE: Biospecimen Collection
OTHER: Exercise Intervention
PROCEDURE: Magnetic Resonance Imaging
Eligibility: Inclusion Criteria: * STUDY 1: Participants must be physically fit enough to perform light exercise. * STUDY 1: Should read and understand English well enough to consent, complete measures, and follow instructions. * STUDY 1: Must have access to a smartphone or tablet. * STUDY 2…
What's being tested:
DIETARY_SUPPLEMENT: Dietary supplement intervention Goodphyte IB Defense
DIETARY_SUPPLEMENT: Dietary supplement intervention Goodphyte Immunity
Eligibility: Inclusion Criteria: * Crohn's disease: Patients in remission, with a stable type of pharmacological treatment over the past 3 months and a stable dosage during the last month. * Ulcerative colitis: Patients in remission, with a stable type of pharmacological treatment over the p…
What's being tested:
DRUG: bioactivated GRA for adult patients
DRUG: bioactivated GRA for pediatric patients
Eligibility: Inclusion Criteria: Inclusion Criteria for PD: * Male or female patients aged between 45-75 years old. * Clinical diagnosis of PD according to UK Brain Bank Criteria. * 3 months of clinical stability before study enrolment. * Anti-parkinsonian medication is fixed for at least 3…
Eligibility: * INCLUSION CRITERIA: * Diagnosis of MS according to consensus criteria at the time of enrollment OR diagnosis of a disease that shares clinical, imaging, or biological features with MS OR individuals without known CNS disease. * Age greater than or equal to 18. * Able to partici…
Eligibility: Inclusion Criteria: Diagnosis of multiple sclerosis (MS) according to the 2017 revised McDonald criteria. Female patients aged 30-50 years (age range with higher prevalence of urinary incontinence in MS). Experiencing urinary incontinence (UI) symptoms according to the Interna…
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Trial data sourced from
ClinicalTrials.gov (U.S. National Library of Medicine). Data may be delayed. Verify enrollment status directly with the research team.