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Lupus Trials
310 recruiting trials found
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🏢Sponsor: Biomedical Research Foundation, Academy of Athens
📍Locations: Athens, Attica, Greece
🎂Age: 18 Years
📅Started: 2025-06-30
Eligibility: Inclusion Criteria: * Systemic lupus erythematosus classification according to the Systemic Lupus International Collaborating Clinics (SLICC) criteria * Age ≥ 18 years old * Time of follow-up ≥ 6 months * Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) ≥ 4 *…
🏢Sponsor: Peking University Third Hospital
📍Locations: Beijing, Beijing Municipality, China
🎂Age: 18 Years – 65 Years
📅Started: 2024-07-30
What's being tested:
BIOLOGICAL: IM19 CAR-T cells
Eligibility: Inclusion Criteria: * 1)The subject was diagnosed with systemic lupus erythematosus and met the classification criteria of EULAR/ACR 2019 SLE (see Annex 2) * 2\) Age ≥ 18 years old, ≤ 65 years old * 3\) Weight ≥ 40 kg * 4\) Meets the current clinical standards for refractory sys…
🏢Sponsor: Mao Jianhua
📍Locations: Hangzhou, Zhejiang, China · Hangzhou, Zhejiang, China
🎂Age: 5 Years
📅Started: 2024-12-08
What's being tested:
DRUG: Blinatumomab 9ug
Eligibility: Inclusion Criteria: Participants must meet all the following criteria to be eligible for enrollment: 1. Age: ≥ 5 years old. 2. Diagnosis: Diagnosed with systemic lupus erythematosus (SLE) based on the 2019 EULAR/ACR classification criteria. 3. Positive Antibody: At least one of…
🏢Sponsor: Medical University of South Carolina
📍Locations: Charleston, South Carolina, United States
🎂Age: 2 Years
📅Started: 2003-04
Eligibility: Inclusion Criteria: * Age 2 years and above; * Self-identified as African-American "Gullah" from the Sea Island region of South Carolina; * Have had at least 4 of the 11 diagnostic criteria for SLE as designated by the American College of Rheumatology (ACR), be a relative of a k…
🏢Sponsor: Cullinan Therapeutics Inc.
📍Locations: Avondale, Arizona, United States · Tucson, Arizona, United States · Orlando, Florida, United States
🎂Age: 18 Years – 70 Years
📅Started: 2025-01-21
What's being tested:
DRUG: CLN-978
Eligibility: Inclusion Criteria: * Diagnosis of SLE at least 24 weeks prior to Screening and meet 2019 EULAR / ACR Classification Criteria at screening. * Presence of one or more of the following autoantibodies documented during screening or in the previous 12 months before screening: positi…
🏢Sponsor: 920th Hospital of Joint Logistics Support Force of People's Liberation Army of China
📍Locations: Kunming, Yunnan, China
🎂Age: 14 Years – 75 Years
📅Started: 2024-10-09
What's being tested:
DRUG: JY231 injection
Eligibility: Inclusion Criteria: 1. Diagnosed with SLE according to the 2019 European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) classification criteria or the 2012 Systemic Lupus Erythematosus International Clinical Collaboration (SLICC) criteria. 2. Must have…
🏢Sponsor: University Hospital, Lille
📍Locations: Lille, France
🎂Age: 18 Years
📅Started: 2020-07-20
What's being tested:
GENETIC: Biobanking with genetic analysis
OTHER: SF-12 questionnaire
Eligibility: Inclusion Criteria: * Patient followed for their IMID in one of the departments of the Lille University Hospital participating in the study (dermatology, internal medicine, neurology, pneumology and rheumatology) * Social insured * Have the capacity to understand the study requi…
🏢Sponsor: AstraZeneca
📍Locations: Wilmington, North Carolina, United States
👤Gender: FEMALE
📅Started: 2025-07-01
What's being tested:
DRUG: Anifrolumab
Eligibility: Inclusion Criteria: Exposed cohort 1. Currently or recently (within 1 year of pregnancy outcome) pregnant 2. Diagnosis of moderate/severe SLE 3. Consent to participate 4. Authorization for their HCP(s) to provide data to the registry 5. Exposure to at least 1 dose of anifroluma…
🏢Sponsor: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
📍Locations: Bethesda, Maryland, United States
🎂Age: 18 Years – 80 Years
📅Started: 2023-12-07
What's being tested:
DRUG: anifrolumab
OTHER: Placebo
Eligibility: * INCLUSION CRITERIA: In order to be eligible to participate in this study, an individual must meet all of the following criteria: 1. Provision of signed and dated informed consent form 2. Stated willingness to comply with all study procedures and availability for the duration…
🏢Sponsor: Viatris Innovation GmbH
📍Locations: Miami, Florida, United States · Miami, Florida, United States · Miami, Florida, United States
🎂Age: 18 Years – 75 Years
📅Started: 2026-02-09
What's being tested:
DRUG: Cenerimod
DRUG: Placebo
Eligibility: Main Inclusion Criteria: * Classification of systemic lupus erythematosus (SLE) made according to the 2019 European Alliance of Associations for Rheumatology / American College of Rheumatology (EULAR/ACR) criteria. * Renal biopsy within 6 months prior to Screening visit indicati…
🏢Sponsor: PersonGen BioTherapeutics (Suzhou) Co., Ltd.
📍Locations: Hefei, China
🎂Age: 18 Years
📅Started: 2024-04-02
What's being tested:
BIOLOGICAL: T cell injection targeting CD19 chimeric antigen receptor
Eligibility: inclusion criteria (2) Expected survival time ≥3 months; (3) Subjects with recurrent/refractory autoimmune diseases who have failed standard treatment or lack effective treatment, Including but not limited to systemic lupus erythematosus, idiopathic inflammatory myopathy, systemi…
🏢Sponsor: University Hospital, Strasbourg, France
📍Locations: Strasbourg, France, France
🎂Age: 18 Years – 70 Years
📅Started: 2024-01-09
Eligibility: Inclusion Criteria: * Patients between 18 and 70 years of age * Patient affiliated to a health insurance scheme (beneficiary or beneficiary's beneficiary) * Patient able to understand the aims and risks of research * Patient having signed and dated an informed consent form * Pat…
🏢Sponsor: Tongji Hospital
📍Locations: Wuhan, Hubei, China
🎂Age: 18 Years – 80 Years
📅Started: 2025-08-25
What's being tested:
DRUG: Methylprednisolone (Corticosteroid)
DRUG: Immunosuppressant other than CYC
DRUG: Telitacicept Freeze-dried powder Injection 80mg
Eligibility: Inclusion Criteria: * Meet the 2019 EULAR/ACR classification criteria for systemic lupus erythematosus; * Male or non-pregnant female aged ≥ 18 years; * Diagnosis by high-resolution lung CT (HRCT) is clearly consistent with interstitial lung disease (ILD); * FEV1/FVC%≥60% and di…
🏢Sponsor: Terry L. Wahls
📍Locations: Iowa City, Iowa, United States
🎂Age: 18 Years – 100 Years
📅Started: 2025-12-01
What's being tested:
BEHAVIORAL: Creating Health Online Course
BEHAVIORAL: Delayed access to Creating Health Online Course
Eligibility: Inclusion criteria: 1. A diagnosis of one of the following: Rheumatoid Arthritis (RA), Sjogren's Syndrome, Systemic lupus erythematosus (SLE), Mixed connective tissue disease (MCTD), or Psoriatic Arthritis (PsA), as documented by their treating specialist or primary care provide…
🏢Sponsor: Genentech, Inc.
📍Locations: Birmingham, Alabama, United States
🎂Age: 18 Years – 75 Years
📅Started: 2026-02-20
What's being tested:
BIOLOGICAL: P-CD19CD20-ALLO1 Cells
DRUG: Cyclophosphamide
DRUG: Fludarabine
Eligibility: Key Inclusion criteria: 18-75 years old SLE diagnosis per 2019 EULAR/ACR classification criteria ≥ 24 weeks Autoantibody positive and low complement at screening Treatment refractory: Failed ≥ 2 treatments for at least 3 months Highly active disease: SLEDAI-2K ≥ 8 (excludin…
🏢Sponsor: Sohag University
📍Locations: Sohag, Egypt
🎂Age: 1 Year
📅Started: 2024-06-01
What's being tested:
DIAGNOSTIC_TEST: Anti Phospholipid antibodies
RADIATION: EEG
Eligibility: Inclusion Criteria: * The study aims to include all children fulfilling the diagnostic criteria of SLE (The European League Against Rheumatism and The American College of Rheumatology (9)) attending to pediatric rheumatology and immunology clinic at Sohag University Hospitals du…
🏢Sponsor: IRIS Research and Development, LLC
📍Locations: Plantation, Florida, United States
🎂Age: 18 Years
📅Started: 2024-05-15
What's being tested:
DRUG: AB-101
DRUG: Rituximab
DRUG: Cyclophosphamide
Eligibility: Inclusion Criteria: General Inclusion Criteria (applicable to subjects in all 4 studied indications) 1. Males or female subjects, ≥ 18 years of age at the time of signing informed consent. 2. Ability to understand the requirements of the study. 3. Willingness to provide written…
🏢Sponsor: Therorna
📍Locations: Shanghai, Shanghai Municipality, China
🎂Age: 18 Years – 65 Years
📅Started: 2026-01-22
What's being tested:
BIOLOGICAL: TI-0032-III injection
Eligibility: Inclusion Criteria: * Understand trial procedures and methods, voluntarily sign the informed consent form . * Age ranges from 18 to 65 years old (including threshold), regardless of gender. * Positive expression of CD19 on peripheral blood B cells determined by flow cytometry. *…
🏢Sponsor: National Cancer Institute (NCI)
📍Locations: Birmingham, Alabama, United States · Palo Alto, California, United States · Sacramento, California, United States
🎂Age: 18 Years
📅Started: 2019-07-16
What's being tested:
PROCEDURE: Biospecimen Collection
BIOLOGICAL: Nivolumab
Eligibility: Inclusion Criteria: * Patients can have either histologically confirmed malignancy that is radiologically evaluable and metastatic or unresectable, or have a malignancy for which a PD-1/PD-L1 inhibitor has been approved in the adjuvant setting. Eligible tumor types include solid…
🏢Sponsor: ASST Fatebenefratelli Sacco
📍Locations: Milan, Italy
🎂Age: 18 Years
👤Gender: FEMALE
📅Started: 2022-04-14
Eligibility: Inclusion Criteria: * All patients over the age of 18 will be enrolled in the study, who will sign the informed consent for participation in the study, characterized by the positivity of autoantibodies against Ro/SSA who will become pregnant during the enrollment period in the e…
Showing 1–20 of 310 results
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Trial data sourced from ClinicalTrials.gov (U.S. National Library of Medicine). Data may be delayed. Verify enrollment status directly with the research team.