What's being tested:
DRUG: Pregabalin and venlafaxine concomitant therapy
DRUG: Esketamine plus pregabalin and venlafaxine concomitant therapy
Eligibility: Inclusion Criteria: * Patients between ages over 18 years with proper cognitive function and language skills for the study; * Patients diagnosed with FM as defined by the ACR FM diagnostic criteria; * Patients who have experienced insufficient symptom relief with non-pharmacolog…
Eligibility: Inclusion Criteria: * Men and women 18-65 years of age * Ability to give informed consent * Symptoms meeting criteria for normal or latent/active temporomandibular myofascial pain Exclusion Criteria: * Contraindications to MRI scanning including severe obesity or difficulty in…
What's being tested:
PROCEDURE: Wet cupping therapy (WCT)
Eligibility: Inclusion Criteria: * Adult patients aged 18-55 years. * Female individuals to avoid the gender confounding factor. * Clinical diagnosis of primary fibromyalgia according to the 2016 American College of Rheumatology (ACR) updated diagnostic criteria. * Moderate pain intensity of…
What's being tested:
OTHER: Electroacupuncture
BEHAVIORAL: Cognitive Training
BEHAVIORAL: Education Training
Eligibility: Inclusion Criteria: * Meet traditional American College of Rheumatology (ACR) criteria for FM as well as the more recent Wolfe et al 2011 criteria * Are on stable doses of medication for 30 days prior to entering the study and agree not to change medications or dosages during th…
What's being tested:
OTHER: Questionnaire study
Eligibility: Inclusion Criteria: * People with musculoskeletal pain and in diagnoses with OA, back pain, or FM * Above 18 years of age * Informed consent of the participant Exclusion Criteria: * Diagnosis of uncontrolled/other clinically significant diseases (chronic obstructive pulmonary…
What's being tested:
RADIATION: ultrasound
Eligibility: Inclusion Criteria: * Patients fulfill the Assessment in Spondyloarthrits International Society (ASAS) classification criteria for Axial Spondyloarthritis. * Age above 18 years old. * Patient cooperative and can answer questions. * Patients who are able and willing to give writt…
What's being tested:
OTHER: Home-based stretching exercises
Eligibility: Inclusion Criteria: * individuals diagnosed with fibromyalgia in accordance with the ACR 2016 diagnostic criteria. * individuals diagnosed with chronic non-malignant pain or individuals diagnosed with chronic widespread pain (including fibromyalgia syndrome) are also included wh…
What's being tested:
OTHER: Electroacupuncture
DIETARY_SUPPLEMENT: Nutrition
DIETARY_SUPPLEMENT: Dietary supplement
Eligibility: Inclusion Criteria: * Patient's consent * Age \>18 years old * Patients with diagnosed fibromyalgia from rheumatologists * Widespread pain more than 6 months * In case of drug therapy, it should be taken at least one month before the beginning of the session and remain stable ti…
What's being tested:
DIAGNOSTIC_TEST: EEG
DIAGNOSTIC_TEST: Neuroimaging EEG/fMRI (Aim 1)
DEVICE: HD-tDCS treatments
Eligibility: Inclusion Criteria For Fibromyalgia Participants: * Satisfy the American College of Rheumatology (2011) survey criteria for the classification of Fibromyalgia (FM). * Continued presence of pain for more than 50% of days for the past month. * Mean recalled pain over the last seve…
What's being tested:
OTHER: Core Shamanism
Eligibility: Inclusion Criteria for Fibromyalgia participants: * Female * Over 18 and under 75 years of age. * Fibromyalgia patients and satisfies the 2016 Fibromyalgia Diagnostic Criteria for the classification of FM. * Mean recalled pain over the last seven days (7-day recall) greater than…
What's being tested:
OTHER: Exercise
OTHER: Dry Needling + Exercise
OTHER: Exercise + interfascial block
Eligibility: Inclusion Criteria: * Myofascial pain in the upper trapezius muscle that has lasted for at least 3 months * VAS score of 4 or higher for the current pain * Clinically diagnosed with myofascial pain in the trapezius muscle * Ages 18 to 55 * Patients who can follow verbal instruct…
What's being tested:
DIAGNOSTIC_TEST: Skin punch biopsy to demonstrate small fiber neuropathy
Eligibility: Inclusion Criteria: * patients over 18 years of age with no age limit - * having given their signed consent to take part in the study * affiliated to the French social security system * able to be followed for the entire duration of the study * reading and understanding French *…
What's being tested:
DRUG: Pregabalin
DRUG: Pregabalin with venlafaxine
Eligibility: Inclusion Criteria: * Diagnosed with FM according to the 2016 Revisions to the 2010/2011 FM diagnostic criteria; * Aged more than 18 years; * Suffering from moderate to severe FM with 11-point numeric rating scale (NRS) score more than 4 at baseline that have not been effectivel…
What's being tested:
OTHER: Rehabilitation
Eligibility: Inclusion Criteria: IRCCS San Raffaele Roma patients who entered the neuro-rehabilitation program, aged 18 years older, able to sign a written informed consent. Exclusion Criteria: * Patients with oncological or psychiatric diseases. * Pregnant patients * Patients with a sever…
What's being tested:
OTHER: Neuropsychological tasks and self-report questionnaires
Eligibility: Inclusion Criteria: * Fibromyalgia syndrome (confirmed by a medical diagnosis); * Able to understand English, Dutch or French; * Signed an informed consent. Exclusion Criteria: * Other diagnoses (osteoarthritis, rheumatoid arthritis, post-cancer pain, as well as patients with…
What's being tested:
BEHAVIORAL: Integrated Rehabilitation Program at the University Museum
OTHER: CARES treatment
Eligibility: Inclusion Criteria: * Female patients * Diagnosis of Fibromyalgia Syndrome according to 2016 criteria * Muscle pain Visual Analogue Scale (VAS) score greater than 5 in the last month * Age between 18 and 60 years * Absence of other chronic, widespread, or localized painful condi…
What's being tested:
BEHAVIORAL: Dynamic interpersonal therapy (DIT)
BEHAVIORAL: technique of expressive writing (TSE)
OTHER: Treatment as Usual (TAU)
Eligibility: Inclusion Criteria: * minimum age of 18 years; * at least 5 years of education; * FM diagnosis according to the criteria reported by Wolfe (2016) for the FM group; * CM diagnosis according to Olesen (2018) for the CM group; * medical certification for FM and CM diagnosis for Fib…
What's being tested:
BEHAVIORAL: Moderate Intensity Continuous Training
Eligibility: Inclusion Criteria: Inclusion Criteria for Veterans living with FM: * Inclusion Criteria (FM) Age 19 years or older * Widespread pain index (WPI) 7 and symptom severity scale (SSS) score 5 OR WPI 4-6 and SSS score 9 * Generalized pain, defined as pain in at least 4 of 5 regions…
What's being tested:
DEVICE: EXOPULSE Mollii Suit and EXOPULSE Suit
Eligibility: Inclusion Criteria: * Diagnosed with CP, MS, stroke, fibromyalgia or other neurologic disorder that may cause such type of symptoms. * Diagnosed \>6 months prior to inclusion in case of MS or stroke as well as \>1 month prior to inclusion in the case of fibromyalgia. * Give writ…
What's being tested:
DRUG: Nitrous oxide gas for inhalation
DRUG: Placebo
Eligibility: Inclusion Criteria: * 2016 American College of Rheumatology Revised criteria for fibromyalgia (2016-ACR) * Subjects 18 -75 years of age. * Self-reported pain of at least 4 on the Numeric Pain Rating Scale (NPRS) at screening and baseline. * Subject receives and agrees to remain…
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Trial data sourced from
ClinicalTrials.gov (U.S. National Library of Medicine). Data may be delayed. Verify enrollment status directly with the research team.