What's being tested:
DIAGNOSTIC_TEST: Magnetoencephalography plus Stereo-electroencephalography/Electrocorticography
DIAGNOSTIC_TEST: Stereo-electroencephalography/Electrocorticography
Eligibility: Inclusion Criteria: 1. Age range: 3-18 years old; 2. Clinically diagnosed with refractory epilepsy; 3. Capable of cooperating with magnetoencephalography evaluation and recording. Exclusion Criteria: 1. Patients with serious comorbidities or neurological or psychiatric disorde…
What's being tested:
BEHAVIORAL: ReACT
Eligibility: Inclusion Criteria: * 9-18 years old. * Diagnosis of psychogenic non-epileptic seizures by a medical doctor using video-EEG. * Family member (parent if a minor) willing to participate and that the subject with PNES chooses. Exclusion Criteria: * Comorbid Epilepsy * Less than 4…
What's being tested:
DEVICE: macro/micro electrode recording
Eligibility: Inclusion Criteria: * Age ≥18 yo * Epilepsy patients undergoing intracranial electrode placement. * Able to understand the procedure involved and to consent. Exclusion Criteria: * Age \< 18 yo * Pregnancy
What's being tested:
OTHER: Survey
Eligibility: Inclusion Criteria: * Epilepsy beginning before 1 month of life, and requiring the initiation of anti-epileptic treatment * Without occasional cause * Without brain malformation explaining epilepsy * No opposition from parents / guardians * Possibility for parents to complete pa…
What's being tested:
DRUG: Lemborexant
DRUG: Placebo
Eligibility: Inclusion Criteria: * Sleep-related focal epilepsy * Contraception Exclusion Criteria: * Changes in antiseizure medication 1 month before study protocol or during study protocol * Concomitant medications per SUNRISE1 * Individuals with hepatic impairment * Female participants…
What's being tested:
PROCEDURE: Laboratory tests
PROCEDURE: Radiological exams
Eligibility: * INCLUSION CRITERIA: 1. Participants must be age 4 and older. 2. Participants must seek care from, or be referred to the Surgical Neurology Branch for evaluation and management of neurosurgical conditions (such as central nervous system tumors, peripheral nerve tumors, epil…
What's being tested:
DEVICE: Acupuncture intervention
Eligibility: Inclusion Criteria: * Patient implanted with the RNS system * Patient can undergo 12 weeks of acupuncture * Patient is able remain on stable medications for 12 weeks * Patient is able to remain on stable Detection and Stimulation settings for 12 weeks * Patient or/and caregiver…
What's being tested:
OTHER: Tomography exam
Eligibility: Inclusion Criteria: * \- Female or male, over 18 and under 65 years of age. * Subject free of any general illness, psychiatric disorders or infectious, inflammatory, tumoral, vascular, degenerative or traumatic pathology of the central nervous system, as determined on examinatio…
What's being tested:
DRUG: Sulthiame
Eligibility: Inclusion Criteria: * Diagnosis of epilepsy syndromes of childhood with sleep activation * Failure of at least two anti-epileptic drugs (AED) * Sleep EEG performed in the last 7 days before inclusion and showing interictal epileptiform discharges (baseline EEG) Exclusion Criter…
What's being tested:
OTHER: acoustics tests, Questionaries,
RADIATION: MRI
Eligibility: Common Criteria for Inclusion : * Age ≥ 18 years old * Good written and oral comprehension of the French language * Person affiliated to a Social Security scheme * Informed consent signed by the participant * Normal or corrected vision * Absence of known pre-existing neurologica…
What's being tested:
DEVICE: Magnetic Resonance Imaging-guided Focused Ultrasound Ablation (MRgFUSA)
Eligibility: Inclusion Criteria: * Disabling, medically refractory epilepsy (≥2 anti-epileptic drug failures). * Focal onset seizures with secondary generalization; with or without primary generalized seizures. * Previous seizure work-up within 12 months of enrollment date to include: A. Ho…
What's being tested:
DRUG: Clemizole HCl
DRUG: Placebo
Eligibility: Key Inclusion Criteria: 1. Male and female participants 2 years and older at time of consent. 2. Participant or parent/legally authorized representative (LAR) willing and able to provide written informed consent, assent (if applicable) prior to initiation of any study related pr…
Eligibility: Inclusion Criteria: Alpha 7/Alpha 9 Integrin Related Myopathy Collagen VI Related Myopathy (Ullrich through Bethlem CMD) Alpha-Dystroglycan Related Muscular Dystrophy (Dystroglycanopathy, WWS, MEB, Fukuyama, FKRP, LGMD2I, LGMD2K, LGMD2M, LGMD2N, LGMD2O) Choline Kinase B Receptor…
Eligibility: Inclusion Criteria: 1. Age 14-80 years old, male and female; 2. Meet the diagnostic criteria for epilepsy, including focal epilepsy and generalized epilepsy. 3. Patients diagnosed with epilepsy, with at least one seizure during the hospitalization. 4. Seizures lasting longer tha…
What's being tested:
DEVICE: patent foramen ovale closure
Eligibility: Inclusion Criteria: 1. Age between 18 and 60 years, with no gender restrictions; 2. Diagnosis of epilepsy in accordance with the International League Against Epilepsy (ILAE) criteria (2014 edition); 3. Drug-resistant epilepsy, defined as failure to achieve sustained seizure free…
Eligibility: Inclusion Criteria: * Patients have a diagnosis of new-onset focal epileptic seizure or epilepsy and present with their first seizure within the previous 12 months * Patients are prospectively recruited from the routine practice of epileptologists in epilepsy centers and epileps…
Eligibility: Inclusion Criteria: * Diagnosis of FND * Can read and write English fluently * Referred to UAB outpatient treatment for FND in physical, occupational, or speech therapy * Referred to UAB outpatient treatment for FND in psychiatry * Referred to inpatient consult for FND at Childr…
Eligibility: Inclusion Criteria: * Neuro-oncological pathology: supratentorial and subtentorial tumors, intra and extra axial tumors excluding the skull base (anterior, middle and posterior fossa; sellar and parasellar region) * Basicranial pathology: tumors originating from the anterior cra…
What's being tested:
DEVICE: Previous receipt of the Minder System (implantable continuous electroencephalographic (EEG) monitoring (iCEM) system)
Eligibility: Inclusion Criteria: * Participant met all inclusion criteria, was enrolled in the DETECT study, and received the Minder device * Participant completed the DETECT study by receiving an actionable event or by completing the 6-month follow-up visit * Participant continues to have t…
What's being tested:
OTHER: Acoustic Stimulation (AS)
OTHER: SHAM Stimulation
Eligibility: Inclusion Criteria: * Age 18 - 40 years of age * Focal Epilepsy * Capacity to fully cooperate and follow directions * no other significant neurological disorders which could affect cognition Exclusion Criteria: * Current use of any medications that can significantly affect cog…
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Trial data sourced from
ClinicalTrials.gov (U.S. National Library of Medicine). Data may be delayed. Verify enrollment status directly with the research team.