What's being tested:
DEVICE: Active tDCS
DEVICE: Sham tDCS
Eligibility: Inclusion Criteria: * Age: 18-65 years (inclusive) * Diagnosis: Confirmed diagnosis of multiple sclerosis (MS), including relapsing-remitting or secondary progressive subtypes * Stable Medications: Stable use of antidepressant and disease-modifying therapies (DMTs) for at least…
What's being tested:
BEHAVIORAL: HeartGPS
Eligibility: Inclusion Criteria 1. Pregnant person carrying a fetus diagnosed with single ventricle congenital heart disease (CHD). 2. Single ventricle CHD diagnosis between 16 and 30 weeks gestation. 3. Singleton pregnancy. 4. Pregnant person is planning to continue with the pregnancy. 5. P…
What's being tested:
BEHAVIORAL: Clips Intervention
DEVICE: Structured Questionnaire Only
Eligibility: Inclusion Criteria: * 1\. The diagnosis of gestational diabetes mellitus. * 2\. No any history of disease\* before the pregnancy or do have history of disease\* without taking any medicines. (\*disease, eg. hypertension, diabetes mellitus, hyperthyroidism...etc.) * 3\. No recurr…
What's being tested:
DRUG: Ketamine Hydrochloride
OTHER: No intervention (placebo)
Eligibility: Inclusion Criteria: * Willing and able to give informed consent for participation in the study * Sufficiently fluent English to understand and complete the tasks * Registered with a GP and consents to GP being informed of participation in the study Participants need to meet a n…
What's being tested:
DRUG: Ketamine
DRUG: Normal Saline
Eligibility: Inclusion Criteria: * Ability to provide informed consent * Meets diagnostic criteria for major depressive disorder without psychotic features per the SCID DSM-IV-TR * PHQ-9 total score ≥ 15 at screening * Treatment-resistant depression, as defined by failure of at least two pre…
What's being tested:
DIETARY_SUPPLEMENT: Sarmentosin - L- theanine
OTHER: Resistance Training
DIETARY_SUPPLEMENT: Placebo Supplement
Eligibility: Inclusion criteria 1. Perimenopausal women between 40 - 55 years 2. Not currently engaging in consistent structured resistance training (defined as \>3 resistance training sessions per week for 4 consecutive weeks, in the past six months). 3. Not on any HRT or hormonal contracep…
What's being tested:
BEHAVIORAL: Reframe-IT and CARIBOU
Eligibility: Inclusion Criteria: * Inclusion Criteria for Educational Institutions * Located in Santiago, Chile. * Secondary education level (grades I-IV Medio). * Coeducational schools. * At least two classes per grade level in secondary education. * A minimum of 30 students per…
What's being tested:
BEHAVIORAL: Rejection and Acceptance Feedback
Eligibility: Inclusion Criteria: * Between ages 13-17 * Depression screening scores on the MFQ-C in the mild (MFQ = 12-25; N = 20) or moderate-to-severe range (MFQ ≥25; N=30) * Possess their own smartphone to complete web-based ecological momentary assessments (EMA) using WebDataExpress. * u…
What's being tested:
BEHAVIORAL: brief culturally adapted behavioral activation
Eligibility: Inclusion Criteria: * scored 10 or above on PHQ-9 * provide informed consent Exclusion Criteria: * having diagnosed of bipolar disorder, psychotic disorders, or substance abuse disorders
What's being tested:
BEHAVIORAL: Emotion Regulation Therapy via Telehealth
Eligibility: Inclusion Criteria: * Between the ages of 18 and 65 * Fluent in English (and therefore able to provide consent) * Currently living in New York State * Access to at least one device with internet and video-conferencing capabilities * High self-reported worry, rumination, and/or s…
What's being tested:
DRUG: Nociceptin Receptor Antagonist
DEVICE: Aversive stimuli
Eligibility: Inclusion criteria for MDD/anxiety disorder group: * DSM-5 diagnostic criteria for MDD, Generalized Anxiety Disorder, Social Phobia, Panic Disorder, Post Traumatic Stress (diagnosed using the SCID-5) * Written informed consent * For MDD subjects, a baseline Hamilton Depression R…
What's being tested:
BEHAVIORAL: Op Volle Kracht
BEHAVIORAL: Gatekeeperstraining
Eligibility: Inclusion Criteria: * Adolescents are in their second or third year of secondary education, ór adolescents will reach the age 14 or 15 in this academic year. * Score above cut-off on depression symptom questionnaire (≥ 14 on the CDI-2; Bodden et al. (2016)). Exclusion Criteria:…
What's being tested:
DRUG: Apimostinel Infusion, Intravenous
BEHAVIORAL: Cognitive Training
BEHAVIORAL: Sham Training
Eligibility: Inclusion Criteria: 1. Participants of any gender are eligible 2. Aged 18 to 60 years 3. Meets Diagnostic and Statistical Manual, Fifth Edition (DSM-V) criteria for major depressive disorder (MDD) 4. MADRS score ≥ 20 at screening 5. Score \>1SD above the normative mean on the Co…
What's being tested:
OTHER: STAT-PC
OTHER: YST-III
Eligibility: Inclusion Criteria: * be aged 18-24 at the time of enrollment * not have received mental health services in the past 90 days, excluding medication and case management * English-speaking * screen positive for suicide risk Exclusion Criteria: * are actively suicidal * have a dev…
What's being tested:
OTHER: EL-SHIN THERAPY
Eligibility: Inclusion Criteria: * Age: Above 18 yrs old * DASS-21 scores: "Moderately Depressed (Score: 14-20)", "Moderately Anxious (Score: 10-14)" \& "Moderately Stressed (Score: 19-25)" * Non-Muslim (Due to legal restriction in Malaysia for this religion) * English literate * Believers…
What's being tested:
DEVICE: Transcranial Magnetic Stimulation
DEVICE: Transcranial Magnetic Stimulation Sham
Eligibility: Inclusion Criteria: 1. Fluent in English and able to volunteer in the informed consent process and provide spontaneous narrative description of key elements, risks, and benefits of the study. 2. Aged 14 years to 18 years, inclusive. 3. Diagnosis of MDD based on psychologist diag…
What's being tested:
BEHAVIORAL: iHeart Depcare tool
Eligibility: Inclusion Criteria: * Over 18 years of age * PHQ9 or PHQ8 score \>=8 * History of coronary heart disease per EHR search for ICD-9 codes of 410-414 and ICD-10 codes: I20, I21, I22, I23, I24, I25. * Appointment with a primary care provider (PCP) or cardiologist in an integrated ca…
What's being tested:
BEHAVIORAL: Cognitive Remediation Training
OTHER: Control Group
Eligibility: Inclusion Criteria * Age 18 to 45 years * Able to speak and read French fluently * Access to a computer with a camera and a secure Internet connection * Access to a private space for assessment and intervention sessions * Available for the complete treatment protocol * Confirmed…
What's being tested:
DEVICE: TBS
Eligibility: Inclusion Criteria: 1. are voluntary and competent to consent to treatment 2. are an outpatient 3. are ≥ 60 years old 4. have a Mini International Neuropsychiatric Interview (MINI 7.0) confirmed diagnosis of MDD, with a current MDE 5. have failed to achieve a clinical response t…
What's being tested:
DEVICE: Active cTBS
DEVICE: Inactive/Sham cTBS
BEHAVIORAL: Imaginal exposure
Eligibility: Inclusion Criteria: * Mild traumatic brain injury (mTBI) defined in accord with the World Health Organization criteria in the last 12 months * age 18-65 at the time of the mTBI * high burden of post-concussive symptoms defined as a score \>=20 on the Rivermead Post-Concussion Sy…
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Trial data sourced from
ClinicalTrials.gov (U.S. National Library of Medicine). Data may be delayed. Verify enrollment status directly with the research team.