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Crohns disease Trials
297 recruiting trials found
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🏢Sponsor: Mount Sinai Hospital, Canada
📍Locations: Toronto, Ontario, Canada
📅Started: 2022-05-01
What's being tested:
GENETIC: Blood or saliva sample collection
Eligibility: Inclusion Criteria: * Subjects: diagnosed with Inflammatory Bowel Disease (Crohn's disease, ulcerative colitis, IBD-undetermined) * Available medical records to confirm IBD diagnosis (Crohn's disease, Ulcerative colitis, IBD undetermined (IBD-U)) * Healthy controls: no personal…
🏢Sponsor: GlaxoSmithKline
📍Locations: Cambridge, United Kingdom
🎂Age: 18 Years – 55 Years
📅Started: 2024-11-18
What's being tested:
DRUG: GSK4528287
DRUG: Placebo
Eligibility: Inclusion Criteria: * Participants who are overtly healthy as determined by medical evaluation including medical history, physical examination, laboratory tests, and cardiac monitoring * White blood cell greater than or equal to (\>=) lower limit of normal (LLN), including both…
🏢Sponsor: American Laboratory Products Company
📍Locations: Miami, Florida, United States · Salem, New Hampshire, United States · Westlake, Ohio, United States
🎂Age: 22 Years
📅Started: 2025-03-25
What's being tested:
DEVICE: ALPCO Calprotectin CLIA
Eligibility: Inclusion criteria: * Male or female, ≥22 years of age (adults) * Suspected inflammatory bowel disease or irritable bowel syndrome with symptoms such as abdominal pain, diarrhea, altered appetite, weight loss, or anemia * Able to provide a sample according to the sampling protoc…
🏢Sponsor: University Hospital, Toulouse
📍Locations: Toulouse, France
🎂Age: 18 Years – 100 Years
📅Started: 2026-02-10
What's being tested:
DIAGNOSTIC_TEST: Inflammatory Bowek Disk Questionnaires
OTHER: Short-International Physical Activity Questionnaries
Eligibility: Inclusion Criteria: * Confirmed diagnosis of Inflammatory Bowel Disease * Crohn's disease in clinical remission (defined by a Harvey Bradshaw Index ≤ 5) or ulcerative colitis in clinical remission (defined by a Mayo score \< 3 and no subscore \> 1) for at least 3 months * Social…
🏢Sponsor: University of Minnesota
📍Locations: Minneapolis, Minnesota, United States
🎂Age: 18 Years – 89 Years
📅Started: 2025-01-15
What's being tested:
BIOLOGICAL: MTP-101C
BIOLOGICAL: MTP-101S
Eligibility: Inclusion Criteria: * Able and willing to provide informed consent. * 18-89 years of age. * English speaking. * Diagnosis of CD based on typical clinical and histologic features. * Active disease on endoscopy: * SES-CD \>= 6 * SES-CD \>= 4 for isolated ileal disease * Curre…
🏢Sponsor: Takeda
📍Locations: Dothan, Alabama, United States · Sun City, Arizona, United States · La Jolla, California, United States
🎂Age: 18 Years – 70 Years
📅Started: 2024-04-18
What's being tested:
DRUG: Vedolizumab
DRUG: Adalimumab
DRUG: Ustekinumab
Eligibility: Inclusion Criteria: Part A: 1. Has a confirmed diagnosis of CD at least 3 months before screening, based on endoscopy results. 2. Has moderately to severely active CD at Screening, defined as an SES-CD \>=6 (\>=4 if isolated ileal disease). 3. Has demonstrated at least 1 of the…
🏢Sponsor: Shaare Zedek Medical Center
📍Locations: Jerusalem, Israel
🎂Age: 6 Years – 18 Years
📅Started: 2024-10-31
What's being tested:
DRUG: Risankizumab
Eligibility: Inclusion Criteria: * Children under the age of 18 years, * Patients diagnosed with CD. * Patients commenced on risankizumab by treating physician (at least one dose), either alone or in combination with any other CD medications, at any stage of the disease. Exclusion Criteria:…
🏢Sponsor: Pontificia Universidad Catolica de Chile
📍Locations: Santiago, Chile
🎂Age: 18 Years – 75 Years
📅Started: 2025-01-24
What's being tested:
DRUG: Infliximab
DRUG: Infliximab
Eligibility: Inclusion Criteria: * Adult inpatients with Crohn's disease, ulcerative colitis or inflammatory bowel disease-unclassified. * Moderate-to-severe flare who fail to iv steroids and require infliximab as per standard of care by treating gastroenterologist Exclusion Criteria: * Pa…
🏢Sponsor: Soroka University Medical Center
📍Locations: Beersheba, Israel · Haifa, Israel · Petah Tikva, Israel
🎂Age: 18 Years – 75 Years
📅Started: 2023-08-01
What's being tested:
BEHAVIORAL: COBMINDEX digital application
BEHAVIORAL: Human therapist (Control)
Eligibility: Inclusion Criteria: * Willingness to participate and signed informed consent * Hebrew-speaking * Age 18-75 * Proven diagnosis of Crohn's disease, at least 3 months post-diagnosis * Stable medical treatment for the last 3 months * Any Harvey Bradshaw Index score * Ability to oper…
🏢Sponsor: Hospices Civils de Lyon
📍Locations: Clermont-Ferrand, France · Grenoble, France · Pierre-Bénite, France
🎂Age: 18 Years – 65 Years
📅Started: 2025-04-08
What's being tested:
OTHER: Sleep activity
OTHER: Questionnaires
Eligibility: Inclusion Criteria: * Patient over 18 and under 65 years of age. * Patient with Inflammatory Bowel Disease diagnosed for at least 3 months. * Patient in remission, for at least 3 months: 1. clinical remission: Harvey-Bradshaw score (HBI) \< 5 for CD and a Mayo score \< 3 for…
🏢Sponsor: The Second Hospital of Nanjing Medical University
📍Locations: Huai'an, Jiangsu, China · Nanjing, Jiangsu, China
📅Started: 2013-02
What's being tested:
PROCEDURE: FMT
Eligibility: Inclusion Criteria: Clinical diagnosis of Crohn's disease, with the diagnosis remaining unchanged after at least three months of follow-up. Willingness to undergo FMT (Fecal Microbiota Transplantation). Exclusion Criteria: Presence of serious conditions that made them unsuita…
🏢Sponsor: Boston Children's Hospital
📍Locations: Boston, Massachusetts, United States · Boston, Massachusetts, United States · New York, New York, United States
🎂Age: 12 Years – 80 Years
📅Started: 2021-03-11
What's being tested:
DRUG: Interleukin-2 (aldesleukin).
Eligibility: Inclusion Criteria: 1. Age 12-80 years. Maximum age limit for subjects recruited at BCH will be 30 years. 2. A diagnosis of CD made by standard clinical, radiological, endoscopic and histological criteria. a. A subset of patients with Ileostomies or colostomies will be permi…
🏢Sponsor: Barts & The London NHS Trust
📍Locations: London, United Kingdom
🎂Age: 16 Years
📅Started: 2024-10-24
Eligibility: Inclusion Criteria: * Patients with inflammatory bowel disease (Crohn's disease, ulcerative colitis or IBD-U) starting a new advanced medical therapy * Patients with inflammatory bowel disease (Crohn's disease, ulcerative colitis or IBD-U) undergoing an IBD-related surgery * Age…
🏢Sponsor: University of California, San Diego
📍Locations: Irvine, California, United States · La Jolla, California, United States · Los Angeles, California, United States
🎂Age: 18 Years
📅Started: 2022-10-05
What's being tested:
OTHER: Pragmatic
Eligibility: INCLUSION CRITERIA: 1. Male or nonpregnant, nonlactating females, ≥ 18 years of age. 2. An established diagnosis of CD or UC for at least 6 months based on standard clinical criteria, confirmed by the treating provider. 3. Current treatment with an approved TIM for treatment of…
🏢Sponsor: University Hospital, Clermont-Ferrand
📍Locations: Amiens, France · Clermont-Ferrand, France · Lille, France
🎂Age: 18 Years
📅Started: 2025-10-13
What's being tested:
BIOLOGICAL: Early faecal calprotectin dosage
Eligibility: Inclusion Criteria: * Patients with an established diagnosis of CD according to ECCO guidelines * Adult Crohn's disease (age ≥ 18 years) * Having undergone ileal, colonic, or ileocolonic resection without residual macroscopic lesions * With an anastomosis that can be reached by…
🏢Sponsor: Janssen Research & Development, LLC
📍Locations: Los Angeles, California, United States · Hartford, Connecticut, United States · Atlanta, Georgia, United States
🎂Age: 2 Years – 17 Years
📅Started: 2024-03-13
What's being tested:
DRUG: Guselkumab
DRUG: Guselkumab
Eligibility: Inclusion Criteria: * Participants must have a diagnosis of Crohn's Disease (CD) or fistulizing CD, with active colitis, ileitis, or ileocolitis, confirmed at any time in the past by clinical, endoscopic, and histologic criteria. * Participants must have moderately to severely a…
🏢Sponsor: National Cancer Institute (NCI)
📍Locations: Birmingham, Alabama, United States · Palo Alto, California, United States · Sacramento, California, United States
🎂Age: 18 Years
📅Started: 2019-07-16
What's being tested:
PROCEDURE: Biospecimen Collection
BIOLOGICAL: Nivolumab
Eligibility: Inclusion Criteria: * Patients can have either histologically confirmed malignancy that is radiologically evaluable and metastatic or unresectable, or have a malignancy for which a PD-1/PD-L1 inhibitor has been approved in the adjuvant setting. Eligible tumor types include solid…
🏢Sponsor: Massachusetts General Hospital
📍Locations: Boston, Massachusetts, United States
🎂Age: 14 Years
📅Started: 2024-12-18
Eligibility: Inclusion Criteria: * Ability to give informed consent * Ability to complete all study visits and study-related procedures * Ability to understand and complete study questionnaires * Must have at least one first-degree relative with inflammatory bowel disease (Crohn's disease, u…
🏢Sponsor: Sakarya University
📍Locations: Sakarya, Adapazarı, Turkey (Türkiye)
🎂Age: 18 Years
📅Started: 2025-11-10
What's being tested:
DIAGNOSTIC_TEST: Muscle Ultrasonography
Eligibility: Inclusion Criteria: * Age ≥18 years * Established diagnosis of inflammatory bowel disease (ICD-10: K50.\* Crohn's disease, K51.\* ulcerative colitis) * Ability to provide written informed consent * Ability to undergo ultrasonographic muscle assessment and handgrip strength testi…
🏢Sponsor: American Laboratory Products Company
📍Locations: Salem, New Hampshire, United States
🎂Age: 22 Years
📅Started: 2025-07-07
What's being tested:
DEVICE: ALPCO Calprotectin CLIA
Eligibility: Inclusion Criteria: * Adults aged ≥22 years No abdominal symptoms and no history of inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), or other chronic intestinal disorders May have undergone colonoscopy with negative findings within the past month or never unde…
Showing 1–20 of 297 results
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Trial data sourced from ClinicalTrials.gov (U.S. National Library of Medicine). Data may be delayed. Verify enrollment status directly with the research team.