Eligibility: For Subjects with Refractory Rheumatoid Arthritis (RA): * Documented diagnosis of RA, meeting the 2010 ACR/EULAR classification criteria. * Rheumatoid Factor (RF) or Anti Citrullinated Protein Antibody (ACPA) positive. * High-sensitivity C-reactive protein (hs-CRP) \> 3 mg/L or…

Eligibility: Inclusion Criteria: 1. Age between 40 and 80 years. 2. Knee OA according to the American College of Rheumatology (ACR) clinical criteria. 3. Knee pain lasting 3 months or longer and a score of 7 or greater on the Western Ontario and McMaster Universities Osteoarthritis Index (WO…

Eligibility: Inclusion Criteria: 1. Meet the 1987 American College of Rheumatology (ACR) classification criteria for RA or the 2010 ACR/European Alliance of Associations for Rheumatology (EULAR) classification criteria for RA. 2. Age \>18 years. 3. Treatment with conventional synthetic DMARD…

Eligibility: Inclusion Criteria: * Study Group; * Having a JIA diagnosis according to ILAR criteria between the ages of 8-16, * Having unilateral knee joint involvement that will affect walking * Being compatible, volunteer and cooperative in the study Control Group; 1. Not having any neu…

Eligibility: Key inclusion criteria: 1. Moderate-to-severe plaque PsO patients who are candidates for bDMARDs, as per provincial reimbursement criteria 2. Adult patients at the time of informed consent signature 3. Patients able to understand and willing to comply with protocol requirements,…

Eligibility: Inclusion Criteria: * 1\) Patients who were previously untreated with MTX, regardless of route of administration 2) Patients aged \>=18 years at the time of informed consent 3) Patients who meet 2010 EULAR/ACR criteria 4) Patients who have disease activity of SDAI \>11 at screen…

Eligibility: Inclusion Criteria: * patients scheduled for total knee arthroplasty * patients aged \>65 and \<100 years * patients can provide informed consent * patients can reliably report symptoms to the research team Exclusion Criteria: * inability to provide first-party consent due to…

Eligibility: Inclusion Criteria: 1. Voluntarily agreed to participate in the study after being informed about the nature of the trial and has signed the informed consent form approved by the IRB. 2. Adults aged 40 to 75 years at the time of screening. 3. Meets the American College of Rheumat…

Eligibility: Inclusion Criteria: * Active plaque psoriasis (PASI ≥3) or Psoriatic Arthritis fulfilling the Classification Criteria for Psoriatic Arthritis (CASPAR) and not meeting MDA criteria * on stable baseline psoriatic treatment for 12 weeks before enrollment * ≥ 18 years old Exclusion…

Eligibility: Inclusion Criteria: * Age \> 40 years * Able to provide informed consent * Knee pain due to osteoarthritis for at least 6 months * Pain refractory to conservative therapies (oral medication, or physical therapy, or activity modification) for at least 3 months with a desire for T…

Eligibility: Inclusion Criteria: * osteoarthritis or avascular necrosis of the femoral head, failed conservative management, indicated for total hip replacement Exclusion Criteria: * reported or documented allergy to chlorhexidine or povidone-iodine

Eligibility: * INCLUSION CRITERIA: Subjects with known or suspected sJIA, AOSD or a similar inflammatory phenotype will provide informed consent and then be evaluated either in the outpatient or inpatient unit of the NIH Clinical Center. To be eligible for follow-up visits patients must meet…

Eligibility: Inclusion Criteria: * Age 18+ years * A self-reported golfer * Able to consent to treatment * Indicated for one of the following surgical procedures: total hip arthroplasty, hip resurfacing, revision hip arthroplasty, total knee arthroplasty, unicompartmental knee arthroplasty,…

Eligibility: Inclusion Criteria: 1. Subject who enrolled K0202 Clinical Trial(parent study) and has been given more than one medication. 2. Subjects who understand and voluntarily sign an informed consent form Exclusion Criteria: 1\. Any other condition which the investigator judges would…

Eligibility: Inclusion Criteria: * 15 years or above. * Displaced longitudinal bucket-handle tear including the posterior horn on MRI and a knee extension deficit. Exclusion Criteria: * Patient younger than 15 years. * Insufficient knowledge of the Swedish language. * Per-operative finding…

Eligibility: Inclusion Criteria: * People with musculoskeletal pain and in diagnoses with OA, back pain, or FM * Above 18 years of age * Informed consent of the participant Exclusion Criteria: * Diagnosis of uncontrolled/other clinically significant diseases (chronic obstructive pulmonary…

Eligibility: Inclusion Criteria: * clinical diagnosis of unilateral osteoarthritis of the knee * presenting knee pain for more than three months * morning stiffness for less than 30 minutes * crepitus, bone tenderness, and absence of palpable heat. Exclusion Criteria: * Bilateral knee oste…

Eligibility: Inclusion Criteria: * Chronic knee pain with pain intensity of at least 4 out 10 on the VAS on most or all days for more than 3 months * Patients of either sex with primary osteoarthritis of one or both knees fulfilling diagnostic criteria for osteoarthritis knee laid down by Am…

Eligibility: * INCLUSION CRITERIA: Known or suspected rheumatic disease Age greater than or equal to 18 years Willingness and capacity to provide informed consent. EXCLUSION CRITERIA: Patients will be excluded if any of the inclusion criteria cannot be met. Women who are pregnant or bre…

Eligibility: Inclusion Criteria: * Patients fulfill the Assessment in Spondyloarthrits International Society (ASAS) classification criteria for Axial Spondyloarthritis. * Age above 18 years old. * Patient cooperative and can answer questions. * Patients who are able and willing to give writt…